Otolaryngology Book

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ChemodectomaAka: Glomus tumor

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  1. Epidemiology
    1. Most common in 40 to 50 year old women
  2. Pathophysiology
    1. Neuroendocrine tumor arising from from glomus bodies
      1. Jugular bulb origin or
      2. Middle ear neural plexus
    2. Tympanic membrane invasion follows Hearing Loss
    3. May involve Cranial Nerves
  3. Symptoms
    1. Pulsating Tinnitus
    2. Hearing Loss
  4. Signs
    1. Dark blue, purple or red-blue mass behind TM
  5. Diagnosis
    1. CT temporal bone
  6. Differential Diagnosis
    1. Anomalous carotid artery
    2. Anomalous jugular bulb
  7. Management
    1. Do not biopsy (very vascular)
    2. Surgical excision

Glomus Tumor (C0017653)

Definition (MSH)A blue-red, extremely painful vascular neoplasm involving a glomeriform arteriovenous anastomosis (glomus body), which may be found anywhere in the skin, most often in the distal portion of the fingers and toes, especially beneath the nail. It is composed of specialized pericytes (sometimes termed glomus cells), usually in single encapsulated nodular masses which may be several millimeters in diameter (From Stedman, 27th ed). CHEMODECTOMA, a tumor of NEURAL CREST origin, is also sometimes called a glomus tumor.
Definition (NCI)A rare benign or malignant mesenchymal neoplasm arising from cells that resemble the modified smooth muscle cells of the glomus body. The majority of glomus tumors occur in the distal extremities.
ConceptsNeoplastic Process (T191)
EnglishGlomus Neoplasm, Glomus Tumor, Glomus Tumors, Glomus tumour
Spanishtumor glomico
Parent ConceptsVascular tissue comprised neoplasm (C0027668), Pericytic Neoplasm (C1335392), Extra-Adrenal Paraganglioma (C0030422), Neoplasms in Vascular Tissue (C0282607), Benign neuroendocrine tumor (C0346416), Paraganglioma AND/OR glomus tumor (C0476130), Benign neuroendocrine neoplasm - category (C1302832), Duplicate concept (C1274013)
SourcesCOSTAR, MSH, MTH, NCI, NDFRT, SCTSPA, SNOMEDCT
Derived from the NIH UMLS (Unified Medical Language System)


Extra-Adrenal Paraganglioma (C0030422)

Definition (MSH)A relatively rare, usually benign neoplasm originating in the chemoreceptor tissue of the CAROTID BODY; GLOMUS JUGULARE; GLOMUS TYPANICUM;, and AORTIC BODIES. It consists histologically of rounded or ovoid hyperchromatic cells that tend to be grouped in an alveolus-like pattern within a scant to moderate amount of fibrous stroma and a few large thin-walled vascular channels. (From Stedman, 27th ed)
Definition (NCI)A benign or malignant paraganglioma arising from sympathetic or parasympathetic paraganglia outside the adrenal gland.
ConceptsNeoplastic Process (T191)
EnglishChemodectoma, Chemodectomas, Extra-Adrenal Paraganglioma, Extra-Adrenal Paragangliomas, Extra-Adrenal Paraganglionic Neoplasm, Extraadrenal Paraganglioma, Non-Chromaffin Paraganglioma, Non-Chromaffin Paragangliomas, Nonchromaffin paraganglioma, Nonchromaffin Paragangliomas
Spanishparaganglioma extradrenal, paraganglioma extrasuprarenal, paraganglioma extrasuprarrenal, paraganglioma no cromafin, quemodectoma
Parent ConceptsParaganglioma (C0030421), Neoplastic disease of uncertain behavior (C0154129), Neuroendocrine Tumors (C0206754), Paraganglioma AND/OR glomus tumor (C0476130), Neoplasm, uncertain whether benign or malignant (C0677041), Ambiguous concept (C1274012), Duplicate concept (C1274013)
SourcesDXP, MSH, MTH, NCI, NDFRT, OMIM, SCTSPA, SNOMEDCT
Derived from the NIH UMLS (Unified Medical Language System)



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