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Botulinum Toxin Injection

Aka: Botulinum Toxin Injection, Onabotulinum Toxin A, Abobotulinum Toxin A, Botulinum Toxin Type A, Botox
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  1. See Also
    1. Skin Cosmetic Procedure
    2. Dermal Filler Injection
  2. Indications
    1. Dynamic facial lines and wrinkles in the upper one third of the face
    2. Frown lines (FDA approved)
    3. Off label uses
      1. Horizontal forehead lines
      2. Wrinkles eminating laterally from lateral canthus region (Crow's feet)
  3. Mechanism
    1. Neurotoxin derived from Clostridium botulinum (cause of Botulism)
    2. Botulinum toxin act neuromuscular junction and inhibits release of acetylcholine
    3. Injection into overactive facial muscles results in localized muscle relaxation
  4. Dosing
    1. One treatment every 3-4 months
  5. Advantages
    1. Brief procedure and highly effective
  6. Disadvantages
    1. Small margin of error for injection site
  7. References
    1. Carruthers (2004) Plast Reconstr Surg 114(6 suppl): 1s-22s
    2. Small (2009) Am Fam Physician 80(11): 1231-8
    3. Wise (2006) Facial Plast Surg 22(2):140-6

Injection of botulinum toxin (C1321035)

Definition (MEDLINEPLUS)

Botox is a drug made from a toxin produced by the bacterium Clostridium botulinum. It's the same toxin that causes a life-threatening type of food poisoning called botulism. Doctors use it in small doses to treat health problems, including

  • Temporary removal of facial wrinkles
  • Severe underarm sweating
  • Cervical dystonia - a neurological disorder that causes severe neck and shoulder muscle contractions
  • Blepharospasm - uncontrollable blinking
  • Strabismus - misaligned eyes

Botox injections work by weakening or paralyzing certain muscles or by blocking certain nerves. The effects last about three to four months. Side effects can include pain at the injection site, flu-like symptoms, headache and upset stomach. Injections in the face may also cause temporary drooping eyelids. You should not use Botox if you are pregnant or breast feeding.

Food and Drug Administration
Concepts Therapeutic or Preventive Procedure (T061)
SnomedCT 404909007
English Botulinum Toxin, Botox, botulinum injection toxin, botulinum injections toxin, injection of botulinum toxin, botulinum toxin injection, Injection of botulinum toxin (procedure), Injection of botulinum toxin
Spanish inyección de toxina botulínica (procedimiento), inyección de toxina botulínica
Sources
Derived from the NIH UMLS (Unified Medical Language System)


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