II. Mechanism

  1. Vesicant obtained from Blister beetle

III. Indications

  1. Stubborn periungual warts
  2. May be useful in Molluscum Contagiosum in children

IV. Obtaining

  1. No longer available is U.S., but available in Canada
  2. Manufactured by Omniderm
    1. Phone: 1-888-458-0158
    2. Fax: 1-514-458-1477

V. Preparations

  1. Cantharidin (Cantharone, Canthacur)
  2. Canthacur PS (w/ Podophyllin 5% + Salicylic Acid 30%)
    1. Reserve for Plantar Warts due to irritation

VI. Precautions

  1. Apply ONLY in office
  2. Avoid touching normal skin

VII. Application

  1. Allow liquid to dry over wart
  2. Then cover with occlusive tape (e.g. Blenderm)
  3. Remove tape after 24 hours
    1. Remove earlier for significant discomfort
  4. In 2-3 days remove Blister under Local Anesthesia
    1. Snip off near base OR Curette
    2. Benefits of removing Blister
      1. Prevents progression to ring wart
      2. Prevents recurrence

VIII. Follow-up

  1. Consider repeat treatment weekly as tolerated

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Ontology: Cantharidin (C0006886)

Definition (MSHCZE) Toxická sloučenina, izolovaná ze španělské mušky (Lytta (Cantharis) vesicatoria) a dalšího hmyzu. Je to silný a specifický inhibitor proteinfosfatas 1 (PP1) a 2A (PP2A). Tato sloučenina může vyvolat silné záněty kůže a požitá orálně je extrémně toxická.
Definition (MSH) A toxic compound, isolated from the Spanish fly or blistering beetle (Lytta (Cantharis) vesicatoria) and other insects. It is a potent and specific inhibitor of protein phosphatases 1 (PP1) and 2A (PP2A). This compound can produce severe skin inflammation, and is extremely toxic if ingested orally.
Concepts Pharmacologic Substance (T121) , Hazardous or Poisonous Substance (T131) , Organic Chemical (T109)
MSH D002193
SnomedCT 437975006, 86218002
English Cantharidin, Cantharidine, 4,7-Epoxyisobenzofuran-1,3-dione, hexahydro-3a,7a-dimethyl-, (3aalpha,4beta,7beta,7aalpha)-, cantharidin (medication), wart therapeutic agents cantharidin, Cantharidin (product), Cantharidin [Chemical/Ingredient], cantharidine, cantharidin, Cantharidin (substance), CANTHARIDIN
Swedish Cantharidin
Czech kantharidin
Finnish Kantaridiini
Russian KANTARIDIN, КАНТАРИДИН
Japanese カンタリジン, カンタリス
Spanish cantaridina (producto), cantaridina (sustancia), cantaridina, Cantaridina
Polish Kantarydyna
French Camphre cantharide, Cantharidine
German Cantharidin
Italian Cantaridina
Portuguese Cantaridina