II. Indication

III. Dosing

  1. Ointment applied qd-bid

IV. Efficacy

  1. Begin to see benefit in 2 weeks
  2. Maximum benefit in 6-8 weeks
    1. Resolution in 10% of patients
    2. Moderate Improvement in 70% of patients
    3. No Improvement in 20% of patients
  3. Useful adjunct to PUVA

V. Adverse effects

  1. May be irritating, more so in fold areas
  2. Do not use on face
  3. Vitamin D analog - risk of Hypercalcemia
    1. Limit to 100 grams per week

VI. Disadvantages

  1. Expensive ($100 for 2 ounces)

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Cost: Medications

calcipotriene (on 8/17/2016 at Medicaid.Gov Survey of pharmacy drug pricing)
CALCIPOTRIENE 0.005% CREAM Generic $3.60 per gram
CALCIPOTRIENE 0.005% OINTMENT Generic $3.59 per gram
CALCIPOTRIENE 0.005% SOLUTION Generic $2.68 per ml
CALCIPOTRIENE-BETAMETH DP OINT Generic $9.70 per gram

Ontology: calcipotriene (C0065767)

Definition (NCI) A synthetic vitamin D derivative usually formulated for topical dermatological use, antipsoriatic Calcipotriene (calcipotriol) competes equally with active 1,25-hydroxy-2D3 (the natural form of vitamin D) for 1,25-hydroxy-2D3 receptors in regulating cell proliferation and differentiation. It induces differentiation and suppresses proliferation of keratinocytes, reversing abnormal keratinocyte changes in psoriasis, and leads to normalization of epidermal growth. (NCI04)
Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH C055085
SnomedCT 108910005, 126232005, 395766004
English 9,10-Secochola-5,7,10(19),22-tetraene-1,3,24-triol, 24-cyclopropyl-, (1alpha,3beta,5Z,7E,22E)-, calcipotriol, 1,24(OH)2-22-ene-24-cyclopropyl D3, calcipotriene, calcipotriene (medication), CALCIPOTRIENE, calcipotriene [Chemical/Ingredient], Calcipotriene (product), Calcipotriol, Calcipotriene preparation (product), Calcipotriene preparation, Calcipotriol (substance), Calcipotriene (substance), Calcipotriene preparation (substance), Calcipotriene
Spanish calcipotrieno (producto), calcipotrieno, preparado con calcipotrieno (producto), preparado con calcipotrieno, calcipotrieno (sustancia), calcipotriol (sustancia), calcipotriol, preparado de calcipotrieno (producto), preparado de calcipotrieno (sustancia), preparado de calcipotrieno