Indication
1. Psoriasis
Dosing
1. Ointment applied qd-bid
Efficacy
1. Begin to see benefit in 2 weeks
2. Maximum benefit in 6-8 weeks
  1. Resolution in 10% of patients
  2. Moderate Improvement in 70% of patients
  3. No Improvement in 20% of patients
3. Useful adjunct to PUVA
Adverse effects
1. May be irritating, more so in fold areas
2. Do not use on face
3. Vitamin D analog - risk of Hypercalcemia
  1. Limit to 100 grams per week
Disadvantages
1. Expensive ($100 for 2 ounces)

Medication Costs
Calcipotriene (on 2/9/2012 at DrugStore.com)
Calcipotriene 0.005% Solution 60ml Bottle	#1 for $339.44	($339.44/unit)
Calcipotriene 0.005% Ointment 60gm Tube	#1 for $280.80	($280.80/unit)
FPNotebook does not benefit financially from showing this medication data or their pharmacy links. This information is provided only to help medical providers and their patients see relative costs. Insurance plans negotiate lower medication prices with suppliers. Prices shown here are out of pocket, non-negotiated rates. See Needy Meds for financial assistance information.

calcipotriene (C0065767)
Definition (NCI)	A synthetic vitamin D derivative usually formulated for topical dermatological use, antipsoriatic Calcipotriene (calcipotriol) competes equally with active 1,25-hydroxy-2D3 (the natural form of vitamin D) for 1,25-hydroxy-2D3 receptors in regulating cell proliferation and differentiation. It induces differentiation and suppresses proliferation of keratinocytes, reversing abnormal keratinocyte changes in psoriasis, and leads to normalization of epidermal growth. (NCI04)
Concepts	Organic Chemical (T109) , Pharmacologic Substance (T121)
MSH	C055085
SnomedCT	108910005, 126232005, 395766004
English	9,10-Secochola-5,7,10(19),22-tetraene-1,3,24-triol, 24-cyclopropyl-, (1alpha,3beta,5Z,7E,22E)-, calcipotriol, 1,24(OH)2-22-ene-24-cyclopropyl D3, calcipotriene, calcipotriene (medication), CALCIPOTRIENE, calcipotriene [Chemical/Ingredient], Calcipotriol, Calcipotriene preparation (product), Calcipotriene preparation, Calcipotriol (substance), Calcipotriene (product), Calcipotriene (substance), Calcipotriene preparation (substance), Calcipotriene
Spanish	calcipotrieno (producto), calcipotrieno, preparado con calcipotrieno (producto), preparado con calcipotrieno, calcipotrieno (sustancia), calcipotriol (sustancia), calcipotriol, preparado de calcipotrieno (producto), preparado de calcipotrieno (sustancia), preparado de calcipotrieno
Sources	Derived from the NIH UMLS (Unified Medical Language System)

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Calcipotriene