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Ciclopirox
Aka: Ciclopirox, Loprox, Penlac- See Also
- Indications
- Dermatophyte Infection (Tinea Corporis)
- Cutaneous Candidiasis
- Tinea Versicolor
- Preparations
- Cutaneous dermatophytes: Ciclopirox olamine 1% (Loprox)
- Onychomycosis: Ciclopirox 8% lacquer (Penlac)
- Mechanism: Broad-spectrum activity
- Antifungal for dermatophytes and yeast
- Some antibacterial activity in vitro
- Efficacy
- Tinea Pedis
- More effective than OTC Clotrimazole (Lotrimin)
- Onychomycosis (not recommended)
- Requires 48 week application
- Minimally better than Placebo for cure rates
- Partial clearance rates are also poor
- Tinea Pedis
| Medication Costs | ||
|---|---|---|
| Ciclopirox Olamine (on 2/9/2012 at DrugStore.com) | ||
| Ciclopirox Olamine 0.77% Suspension 30ml Bottle | #1 for $44.99 | ($44.99/unit) |
| Ciclopirox Olamine 0.77% Suspension 60ml Bottle | #1 for $95.99 | ($95.99/unit) |
| Ciclopirox Olamine 0.77% Cream 30gm Tube | #1 for $44.99 | ($44.99/unit) |
| Ciclopirox Olamine 0.77% Cream 15gm Tube | #1 for $25.99 | ($25.99/unit) |
| Ciclopirox (on 2/9/2012 at DrugStore.com) | ||
| Ciclopirox 1% Shampoo 120ml Bottle | #1 for $135.99 | ($135.99/unit) |
| Ciclopirox 0.77% Gel 100gm Tube | #1 for $175.98 | ($175.98/unit) |
| Ciclopirox 0.77% Gel 30gm Tube | #1 for $75.99 | ($75.99/unit) |
| Ciclopirox 0.77% Gel 45gm Tube | #1 for $120.99 | ($120.99/unit) |
| Ciclopirox 8% Solution 6.6ml Bottle | #1 for $19.99 | ($19.99/unit) |
| Loprox (on 2/9/2012 at DrugStore.com) | ||
| Loprox 1% Shampoo 120ml Bottle | #1 for $322.00 | ($322.00/unit) |
| Loprox 0.77% Gel 100gm Jar | #1 for $482.98 | ($482.98/unit) |
| Loprox 0.77% Gel 30gm Tube | #1 for $183.96 | ($183.96/unit) |
| Loprox 0.77% Gel 45gm Tube | #1 for $280.80 | ($280.80/unit) |
| FPNotebook does not benefit financially from showing this medication data or their pharmacy links. This information is provided only to help medical providers and their patients see relative costs. Insurance plans negotiate lower medication prices with suppliers. Prices shown here are out of pocket, non-negotiated rates. See Needy Meds for financial assistance information. | ||
Penlac (C1130459) |
|
|---|---|
| Concepts | Organic Chemical (T109) , Pharmacologic Substance (T121) |
| MSH | C011585 |
| English | penlac, Penlac |
| Sources |
Derived from the NIH UMLS (Unified Medical Language System) |
ciclopirox (C0055711) |
|
|---|---|
| Definition (NCI) | A synthetic, broad-spectrum antifungal agent with additional antibacterial and anti-inflammatory activities. Ciclopirox exerts its action by binding to and chelating trivalent cations, such as Fe3+ and Al3+, thereby inhibiting the availability of essential co-factors for enzymes. This may lead to a loss of activity of enzymes that are essential for cellular metabolism, organization of cell wall structure and other crucial cell functions. In addition, ciclopirox exerts its anti-inflammatory activity by inhibiting 5-lipoxygenase and cyclooxygenase (COX). |
| Concepts | Organic Chemical (T109) , Pharmacologic Substance (T121) |
| MSH | C011585 |
| SnomedCT | 372854000, 79736009 |
| English | ciclopirox, cyclopirox, ciclopirox (medication), CICLOPIROX, ciclopirox [Chemical/Ingredient], Ciclopirox, Ciclopirox (product), Ciclopirox (substance) |
| Spanish | ciclopirox (producto), ciclopirox (sustancia), ciclopirox |
| Sources |
Derived from the NIH UMLS (Unified Medical Language System) |
Loprox (C0733447) |
|
|---|---|
| Concepts | Organic Chemical (T109) , Pharmacologic Substance (T121) |
| MSH | C011585 |
| English | Loprox, loprox |
| Sources |
Derived from the NIH UMLS (Unified Medical Language System) |