Dermatology Book

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TazaroteneAka: Tazorac

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  1. Mechanism
    1. Retinoid
    2. Suppresses epidermal thickening, Scaling
  2. Dosing
    1. Applied each day
    2. Quick onset of benefit
    3. Start at 0.05% gel, may advance to 0.1% gel
  3. Efficacy
    1. Under 50% have moderate to marked benefit
    2. Best used in combination with topicals
    3. Benefit may last for several weeks after stopping
  4. Side Effects
    1. Erythema in almost everyone
    2. Not tolerated by 10% of patients
    3. Risk of Koebner Reaction
      1. Results in larger area Psoriasis
      2. Apply strictly to lesion

tazarotene (C0288792)

Definition (NCI)A synthetic, topical retinoid. Tazarotene induces the expression of tazarotene-induced gene 3 (TIG3), a tumor suppressor gene. In psoriasis, tazarotene normalizes abnormal keratinocyte differentiation and reduces their hyperproliferation. (NCI04)
ConceptsOrganic Chemical (T109) , Pharmacologic Substance (T121)
MSHC086827
Englishtazarotene, TAZAROTENE PREPARATION
Spanishtazaroteno
Parent ConceptsRetinoids (C0035339), Nicotinic Acids (C0028049), [DE752] ANTIACNE AGENTS, TOPICAL (C0973530), Duplicate concept (C1274013), Dermatological Retinoids (C1579282)
SourcesMSH, MTHSPL, NCI, NDFRT, RXNORM, SCTSPA, SNOMEDCT, USPMG, VANDF
Derived from the NIH UMLS (Unified Medical Language System)


Tazorac (C0723607)

ConceptsOrganic Chemical (T109) , Pharmacologic Substance (T121)
MSHC086827
EnglishTazorac
SourcesMSH, NCI, RXNORM
Derived from the NIH UMLS (Unified Medical Language System)



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