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TazaroteneAka: Tazorac
- Mechanism
- Retinoid
- Suppresses epidermal thickening, Scaling
- Dosing
- Applied each day
- Quick onset of benefit
- Start at 0.05% gel, may advance to 0.1% gel
- Efficacy
- Under 50% have moderate to marked benefit
- Best used in combination with topicals
- Benefit may last for several weeks after stopping
- Side Effects
- Erythema in almost everyone
- Not tolerated by 10% of patients
- Risk of Koebner Reaction
- Results in larger area Psoriasis
- Apply strictly to lesion
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| Definition (NCI) | A synthetic, topical retinoid. Tazarotene induces the expression of tazarotene-induced gene 3 (TIG3), a tumor suppressor gene. In psoriasis, tazarotene normalizes abnormal keratinocyte differentiation and reduces their hyperproliferation. (NCI04) |
| Concepts | Organic Chemical (T109)
, Pharmacologic Substance (T121)
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| English | tazarotene, TAZAROTENE PREPARATION |
| Spanish | tazaroteno |
| Credits | Derived from the NIH UMLS (Unified Medical Language System)
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