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PermethrinAka: Elimite, Nix, Pyrethroid

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  1. See Also
    1. Pesticide
  2. Background
    1. Pyrethroid (Synthetic based on Pyrethrins)
  3. Indications
    1. Pediculosis (Lice)
    2. Scabies
    3. Prevention of Vector-borne Infection
  4. Advantages
    1. Residual activity for over 2 weeks
  5. Precautions
    1. Avoid in under age 2 months old
    2. Safe: Poorly absorbed
    3. Rapidly metabolized to inactive
  6. Pregnancy and Lactation
    1. Pregnancy Category B
    2. Lactation safety is unknown
      1. Consider switching to formula while using permethrin
  7. Preparations
    1. Permethrin 1% (Nix rinse supplied as 60 ml)
      1. Over the counter
    2. Permethrin 5% (Elimite supplied as 60 g cream)
      1. FDA indication only for Scabies
  8. Dosing
    1. Scabies treatment (Permethrin 5%)
      1. Apply Permethrin 5% cream from head to soles of feet
        1. Adults and children over age 5 apply from neck down
      2. Avoid Mouth, nose and eyes
      3. Wash after 8-14 hours
      4. Repeat in one week
    2. Lice treatment (Permethrin 1%)
      1. Apply to clean dry hair
      2. Saturate hair and scalp
      3. Wash after 10 minutes
      4. Consider overnight treatment
        1. Leave on overnight for 8-14 hours under shower cap
        2. Rinse hair in morning
      5. Repeat in one week
  9. Supply
    1. Adult: 60 grams per adult per treatment (120 g total)
    2. Child: 30 grams per child per treatment (60 g total)
  10. Efficacy
    1. Resistance increasing to 1% Permethrin
    2. Lice Treatment may require 5% Permethrin
  11. Adverse Effects
    1. See Pyrethrin
  12. References
    1. Mumcuoglo (1995) Med Vet Entomol 9:427
    2. Rupes (1995) Cent Eur J Public Health 3:30

Permethrin (C0070455)

Definition (MSH)A pyrethroid insecticide commonly used in the treatment of LICE INFESTATIONS and SCABIES.
Definition (NCI)A synthetic pyrethroid and neurotoxin. Permethrin affects the neuronal membrane by blocking the movement of sodium ions from outside to inside the neuronal cell membrane thereby disrupting the sodium channel current that regulates the polarization of the membrane. This leads to delayed repolarization and subsequent paralysis of the nervous system. Permethrin is used to eradicate parasites such as head lice, ticks and scabies from humans and animals.
ConceptsOrganic Chemical (T109) , Pharmacologic Substance (T121) , Hazardous or Poisonous Substance (T131)
MSHD026023
EnglishPermethrin, PERMETHRIN PREPARATION
Spanishpermetrina
Parent ConceptsPyrethrins (C0034245), Pediculicide (C0304599), Miscellaneous topical preparations (C0360289), Medicament biocide (C0444614), Pyrethroids (C0597329), Pediculicides/Scabicides (C0304598)
SourcesMSH, MTH, MTHSPL, NCI, NDFRT, RXNORM, SCTSPA, SNOMEDCT, USPMG, VANDF
Derived from the NIH UMLS (Unified Medical Language System)


Pyrethroids (C0597329)

Definition (CSP)active insecticidal constituents of pyrethrum (Chrysanthemum cinerariifolum) flowers.
ConceptsOrganic Chemical (T109) , Hazardous or Poisonous Substance (T131)
MSHD011722
Englishpyrethroid, Pyrethroid insecticide, Pyrethroids
Parent Conceptsplant insecticide (C0021577), Insecticides (C0021576)
SourcesCSP, MSH, SCTSPA, SNOMEDCT
Derived from the NIH UMLS (Unified Medical Language System)


Elimite (C0720177)

ConceptsOrganic Chemical (T109) , Pharmacologic Substance (T121)
MSHD026023
EnglishElimite
SourcesMSH, RXNORM
Derived from the NIH UMLS (Unified Medical Language System)


BNIP3L gene (C1332435)

Definition (NCI)This gene is involved in the regulation of apoptosis and induces cell death.
ConceptsGene or Genome (T028)
EnglishBCL2/ADENOVIRUS E1B 19-KD PROTEIN-INTERACTING PROTEIN 3-LIKE, BCL2/Adenovirus E1B 19kd Interacting Protein 3-Like Gene, BCL2/adenovirus E1B 19kDa interacting protein 3-like, BNIP3a, BNIP3L, BNIP3L gene, NIX
Parent ConceptsApoptosis Promoter Gene (C1332323)
SourcesHUGO, MTH, NCI, OMIM
Derived from the NIH UMLS (Unified Medical Language System)



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