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PodophyllotoxinAka: Condylox, Podofilox

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  1. Indication
    1. Home application for Genital Warts
  2. Contraindications
    1. Not recommended for mucosal lesions
      1. Avoid on perianal, rectal, urethral, vaginal warts
  3. Preparation
    1. Purified form of podophyllotoxin extract
    2. Podofilox (Condylox) 0.5% solution or gel
      1. Apply solution with cotton swab
      2. Apply Gel with finger (easier to apply)
  4. Advantages
    1. Less irritating and as effective than Podophyllin
    2. Can use in conjunction with other methods
  5. Technique
    1. Cycle application
    2. Apply bid for 3 days
    3. Wait 1-3 days, then restart application cycle
    4. Repeat cycle for up to 4 cycles (maximum 10 cm^2)
  6. Precautions
    1. Allow to dry before moving around
    2. Do not wash off
    3. Do not exceed 0.5 ml per day
  7. Efficacy
    1. Works best on moist mucosal skin sites
    2. Does not work on keratinized Epidermis

podophyllotoxin (C0032334)

Definition (MSH)A lignan (LIGNANS) found in PODOPHYLLIN resin from the roots of PODOPHYLLUM plants. It is a potent spindle poison, toxic if taken internally, and has been used as a cathartic. It is very irritating to skin and mucous membranes, has keratolytic actions, has been used to treat warts and keratoses, and may have antineoplastic properties, as do some of its congeners and derivatives.
Definition (NCI)A pure, stabilized form of podophyllin, in which only the biologically active portion of the compound is present. Podophyllotoxin is a toxic, polycyclic antimitotic agent isolated primarily from the rhizome of the plant Podophyllum peltatum. This agent is formulated for topical applications. (NCI04)
ConceptsOrganic Chemical (T109) , Pharmacologic Substance (T121)
MSHD011034
EnglishPodofilox, PODOFILOX PREPARATION, podophyllotoxin, Podophyllotoxin product
Spanishpodofilotoxina, podofilox, preparacion con podofilotoxina, preparacion con podofilox, producto con podofilotoxina
Parent ConceptsTetrahydronaphthalenes (C0039673), Lignans (C0064971), Colchicine-Site Binding Agent (C1880116), [DE500] KERATOLYTICS/CAUSTICS, TOPICAL (C0991604), Antimitotic Agents (C0003379), Tetrahydronaphthalene (C0039672), Plant alkaloid (C0301258), Duplicate concept (C1274013), Dermatological Mitotic Inhibitors (C1579278)
SourcesLCH, MSH, MTH, MTHSPL, NCI, NDFRT, RXNORM, SCTSPA, SNOMEDCT, USPMG, VANDF
Derived from the NIH UMLS (Unified Medical Language System)


Condylox (C0700937)

ConceptsOrganic Chemical (T109) , Pharmacologic Substance (T121) , Hazardous or Poisonous Substance (T131)
MSHD011034
EnglishCondylox, Oclassen Brand of Podophyllotoxin, Wolff Brand of Podophyllotoxin
SourcesMSH, RXNORM
Derived from the NIH UMLS (Unified Medical Language System)



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