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Podophyllin ResinAka: Podophyllin

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  1. Indications
    1. Wart Treatment
  2. Preparation
    1. Podophyllin 15-25% solution in tincture of Benzoin
  3. Technique
    1. Apply with cotton applicator
    2. Apply test first to small area of warts
    3. Wash off in 4-6 hours (earlier if burning)
    4. Repeat application at 1-2 weeks
  4. Precautions
    1. Perform only in office, not at home
    2. Do not apply more than 0.5 ml
    3. Severe local irritation if
      1. Prolonged, excessive applications, high concentration
      2. Under prepuce can be very irritating
    4. Avoid during pregnancy
    5. Do not treat large area at one time
      1. Risk of systemic absorption leading to toxicity
      2. Toxicity may result in Convulsions or death
    6. Do not apply to mucosa (e.g. vagina, cervix, anus)
      1. Risk of dysplasia
    7. Do not use in infants

podophyllin (C0032333)

Definition (MSH)Caustic extract from the roots of Podophyllum peltatum and P. emodi. It contains PODOPHYLLOTOXIN and its congeners and is very irritating to mucous membranes and skin. Podophyllin is a violent purgative that may cause CNS damage and teratogenesis. It is used as a paint for warts, skin neoplasms, and senile keratoses.
Definition (CSP)caustic extract from the roots of Podophyllum species; it contains podophyllotoxin and its congeners and is very irritating to mucous membranes and skin; it is a violent purgative that may cause CNS damage and teratogenesis; used as a paint for warts, skin neoplasms, and senile keratoses.
Definition (NCI)A resin extracted from the root of the plant Podophyllum sp. Berberidaceae (mandrake), which contains numerous compounds, among which podophyllotoxin is the principal active component. Podophyllin arrests mitosis in metaphase. Podophyllotoxin offers advantages over podophyllin in terms of purity, stability and lack of systemic toxicity. (NCI04)
ConceptsOrganic Chemical (T109) , Pharmacologic Substance (T121) , Biologically Active Substance (T123)
EnglishMayapple Extract, podophyllin, PODOPHYLLIN PREPARATION, Podophyllin Resin, Podophyllum Resin
Spanishpodofilina, podofilino, resina de podófilo, resina de podofilino, resina de podofilo
CreditsDerived from the NIH UMLS (Unified Medical Language System)



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