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MalathionAka: Ovide

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  1. Preparations
    1. Malathion 0.5% in Isopropanol 78% (Ovide Lotion)
  2. Indications
    1. Resistant Head Lice
  3. Mechanism
    1. Irreversible cholinesterase inhibitor (Pesticide)
  4. Efficacy
    1. Highly pediculicidal (kills lice)
    2. Highly ovicidal (kills eggs)
    3. Offers residual protection by binding hair
    4. Resistance has been reported
  5. Directions for use
    1. Apply lotion to dry hair until hair and scalp is wet
    2. Wash hair after 8 to 12 hours
    3. Remove nits with fine-tooth comb
    4. Re-treat in 7 to 9 days (if needed)
  6. Adverse Effects
    1. Very safe
      1. Little if any systemic absorption at this dose
    2. Stinging and irritation secondary to Alcohol base
  7. Precautions
    1. Flammable - keep away from flame or heat source
    2. Keep lotion away from eyes
    3. No recommended for infants
  8. References
    1. (1999) Med Lett Drugs Ther 41(1059):73

Malathion (C0024547)

Definition (MSH)A wide spectrum aliphatic organophosphate insecticide widely used for both domestic and commercial agricultural purposes.
Definition (NCI)A synthetic phosphorous compound and cholinesterase inhibitor that is strictly used as a topical pediculicide. Malathion exerts its action on the nervous system of the lice by irreversibly inhibiting the activity of cholinesterase, thereby allowing acetylcholine to accumulate at cholinergic synapses and enhancing cholinergic receptor stimulation. This eventually leads to the head lice's death.
ConceptsOrganophosphorus Compound (T115) , Pharmacologic Substance (T121) , Hazardous or Poisonous Substance (T131)
MSHD008294
EnglishCarbafos, Carbofos, Carbophos, Karbofos, Malathion, MALATHION PREPARATION, Malathion product
Spanishmalation
Parent ConceptsOrganothiophosphorus Compounds (C0029258), Pediculicide (C0304599), Organophosphate insecticide (C0021580), Pesticides (C0031253), Pediculicides/Scabicides (C0304598)
SourcesCSP, LNC, MSH, MTHSPL, NCI, NDFRT, RXNORM, SCTSPA, SNOMEDCT, USPMG, VANDF
Derived from the NIH UMLS (Unified Medical Language System)


Ovide (C0876117)

ConceptsOrganophosphorus Compound (T115) , Pharmacologic Substance (T121)
EnglishOvide
SourcesNCI, RXNORM
Derived from the NIH UMLS (Unified Medical Language System)



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