Dermatology Book

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LindaneAka: Kwell, Organochlorine

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  1. See Also
    1. Pesticide
  2. Precautions
    1. Do not use in infants
    2. Much greater risk of toxicity than with other agents
    3. Percutaneous absorption 20 fold over Permethrin
    4. CNS toxicity 2-4 fold over Permethrin
      1. Seizure risk in epileptics and children
  3. Mechanism
    1. Organochlorine similar to DDT
    2. Organochlorine Agents
      1. Chlorobenzilate
      2. Dicofol
      3. Dienochlor
      4. Endosulfan
      5. Lindane
  4. Indications
    1. Scabies
    2. Lice
  5. Preparation
    1. Lindane 1% Shampoo (60 ml)
    2. Lindane 1% Lotion (60 ml)
  6. Directions for use
    1. Scabies
      1. Apply lotion to skin from neck to toes
      2. Wash off in 6 to 8 hours
      3. Repeat application in 1 week
    2. Lice
      1. Apply Shampoo to dry hair
      2. Massage into hair for 4 minutes before rinsing
      3. Rinse thoroughly and comb with fine tooth comb
      4. Repeat treatment in one week
  7. Adverse Effects
    1. Mechanism
      1. Disrupts axonal sodium and potassium flow
      2. Affects both central and peripheral nerves
      3. Higher toxicity in broken skin and young children
    2. Effects: Neurotoxicity
      1. Seizure
      2. Headache
      3. Paresthesias
      4. Incoordination
      5. Tremor
    3. Management of toxicitiy
      1. Skin Decontamination
      2. ABC Management
      3. Seizure control with Diazepam
      4. Intravenous fluids (D5W) with Thiamine
  8. References
    1. Meinking (1996) Arch Dermatol 132:959

Lindane (C0005038)

Definition (MSH)An organochlorine insecticide that has been used as a pediculicide and a scabicide. It has been shown to cause cancer.
Definition (CSP)gamma isomer of benzene hexachloride, a carcinogenic insecticide more potent than DDT (chlorophenothane); it is used to kill lice and mites, applied topically to the skin.
Definition (NCI)The gamma-isomer of benzene hexachloride, a colorless to white colored, synthetic, crystalline solid with a slight musty odor that emits toxic fumes of hydrochloric acid and other chlorinated compounds when heated to decomposition. Lindane is used as an insecticide for hardwood logs, lumber, and crops. Lindane also has topical pediculicide and scabicide activities probably due to its neurotoxic effects. Inhalation exposure to this substance causes severe irritation of the nose and throat, causes anemia, and affects the liver, nervous, cardiovascular, and immune system. Lindane is reasonably anticipated to be a human carcinogen.
ConceptsOrganic Chemical (T109) , Pharmacologic Substance (T121) , Hazardous or Poisonous Substance (T131)
MSHD001556
EnglishBenzene Hexachloride, g-Benzene Hexachloride, gamma Benzene hexachloride, gamma hexachlor, gamma Hexachlorocyclohexane, gamma-Benzene Hexachloride, gamma-HCH, gamma-Hexachlorocyclohexane, Gammahexachlorcyclohexane, Gammahexachlorocyclohexane, Hexachlorane, Hexachlorocyclohexane, Lindane, LINDANE PREPARATION, Lindane product
Spanishhexaclorociclohexano, hexacloruro de benceno, hexacloruro de gamma benceno, lindano
Parent ConceptsOrganochlorine insecticide (C0021579), Hydrocarbons, Chlorinated (C0020247), Chlorinated Ring Carcinogen (C1707388), Pediculicide (C0304599), Halogenated hydrocarbon insecticide (C0301163), Scabicide (C0302289), Chlorinated pesticide (C0360424), Organochlorine pesticide (C0392143), Duplicate concept (C1274013), Occupational allergen (C1320243), Pediculicides/Scabicides (C0304598)
SourcesCSP, LNC, MSH, MTHSPL, NCI, NDFRT, RXNORM, SCTSPA, SNOMEDCT, USPMG, VANDF
Derived from the NIH UMLS (Unified Medical Language System)


Hydrocarbons, Chlorinated (C0020247)

Definition (MSH)Hydrocarbon compounds with one or more of the hydrogens replaced by CHLORINE.
Definition (CSP)organic compound that contains carbon and hydrogen, with chlorine atoms substituting for one or more hydrogens.
Definition (NCI)Organochlorines are a group of compounds belonging to the chlorinated hydrocarbon pesticides (as aldrin, DDT, or dieldrin). These compounds are believed to associated with many cancers, especially with breast cancer.
ConceptsOrganic Chemical (T109)
MSHD006843
EnglishChlorinated hydrocarbon, Chlorinated Hydrocarbons, chlorohydrocarbon, Chlorohydrocarbons, Hydrocarbons.chlorinated, Organic Chlorine Compounds, Organochlorine Compound, Organochlorine Compounds, ORGANOCHLORINE CPDS, Organochlorines
Spanishhidrocarburo clorado
Parent ConceptsHydrocarbons, Halogenated (C0020250), Organic Chemicals (C0029224), Organic chloride compound (C0369762)
SourcesAOD, CSP, LCH, LNC, MSH, NCI, NDFRT, SCTSPA, SNOMEDCT
Derived from the NIH UMLS (Unified Medical Language System)


Kwell (C0591692)

ConceptsOrganic Chemical (T109) , Pharmacologic Substance (T121)
MSHD001556
EnglishKwell
SourcesMSH, RXNORM
Derived from the NIH UMLS (Unified Medical Language System)



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