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DifferinAka: Adapalene

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  1. Indication
    1. Acne Vulgaris
  2. Mechanism
    1. Comedolytic
    2. Synthetic retinoid analog
  3. Supplied
    1. Gel 0.1%
  4. Adverse Effects
    1. Same as Tretinoin, but may be less severe
  5. Efficacy
    1. As effective as Tretinoin at the same price
    2. Possibly better tolerated than Tretinoin
  6. Reference
    1. (1997) Med Lett Drugs Ther 39:19

adapalene (C0165631)

Definition (NCI)A topical retinoid-like compound, chemically similar to vitamin A. Although the exact mechanism of action is unknown, adapalene binds to specific retinoic acid receptors in the nucleus, leading to specific gene expression. This agent stimulates skin growth through modulation of cellular differentiation, inflammatory processes and keratinization of follicular epithelial cells. Adapalene may increase dermal sensitivity to ultraviolet radiation. (NCI04)
ConceptsOrganic Chemical (T109) , Pharmacologic Substance (T121)
MSHC063610
Englishadapalene, Adapalene - chemical, ADAPALENE PREPARATION
Spanishadapaleno
Parent ConceptsRetinoids (C0035339), Naphthalenes (C0027378), [DE752] ANTIACNE AGENTS, TOPICAL (C0973530), Duplicate concept (C1274013)
SourcesMSH, MTHSPL, NCI, NDFRT, RXNORM, SCTSPA, SNOMEDCT, VANDF
Derived from the NIH UMLS (Unified Medical Language System)


Differin (C0593946)

ConceptsOrganic Chemical (T109) , Pharmacologic Substance (T121)
MSHC063610
EnglishAllphar brand of adapalene, Differin, Differine, Galderma brand of adapalene
SourcesMSH, NCI, RXNORM
Derived from the NIH UMLS (Unified Medical Language System)



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