Dermatology Book

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CalcipotrieneAka: Donovex

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  1. Indication
    1. Psoriasis
  2. Dosing
    1. Ointment applied qd-bid
  3. Efficacy
    1. Begin to see benefit in 2 weeks
    2. Maximum benefit in 6-8 weeks
      1. Resolution in 10% of patients
      2. Moderate Improvement in 70% of patients
      3. No Improvement in 20% of patients
    3. Useful adjunct to PUVA
  4. Adverse effects
    1. May be irritating, more so in fold areas
    2. Do not use on face
    3. Vitamin D analog - risk of Hypercalcemia
      1. Limit to 100 grams per week
  5. Disadvantages
    1. Expensive ($100 for 2 ounces)

calcipotriene (C0065767)

Definition (NCI)A synthetic vitamin D derivative usually formulated for topical dermatological use, antipsoriatic Calcipotriene (calcipotriol) competes equally with active 1,25-hydroxy-2D3 (the natural form of vitamin D) for 1,25-hydroxy-2D3 receptors in regulating cell proliferation and differentiation. It induces differentiation and suppresses proliferation of keratinocytes, reversing abnormal keratinocyte changes in psoriasis, and leads to normalization of epidermal growth. (NCI04)
ConceptsOrganic Chemical (T109) , Pharmacologic Substance (T121)
MSHC055085
Englishcalcipotriene, Calcipotriene preparation, Calcipotriol
Spanishcalcipotrieno, calcipotriol, preparado con calcipotrieno, preparado de calcipotrieno
Parent ConceptsAnti-psoriatic Agent (C1516001), Calcitriol (C0006674), [DE802] ANTIPSORIATICS, TOPICAL (C0991606), Antimitotic Agents (C0003379), Vitamin D (C0042866), Duplicate concept (C1274013), Topical skin agent (C1629038), Dermatological Vitamin D Analogs (C1579284)
SourcesMSH, MTHSPL, NCI, NDFRT, RXNORM, SCTSPA, SNOMEDCT, USPMG, VANDF
Derived from the NIH UMLS (Unified Medical Language System)



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