Dermatology Book

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CiclopiroxAka: Loprox, Penlac

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  1. See Also
    1. Topical Antifungal
  2. Indications
    1. Dermatophyte Infection (Tinea Corporis)
    2. Cutaneous Candidiasis
    3. Tinea Versicolor
  3. Preparations
    1. Cutaneous dermatophytes: Ciclopirox olamine 1% (Loprox)
    2. Onychomycosis: Ciclopirox 8% lacquer (Penlac)
  4. Mechanism: Broad-spectrum activity
    1. Antifungal for dermatophytes and yeast
    2. Some antibacterial activity in vitro
      1. Gram Positive Bacteria
      2. Gram Negative Bacteria
  5. Efficacy
    1. Tinea Pedis
      1. More effective than OTC Clotrimazole (Lotrimin)
    2. Onychomycosis (not recommended)
      1. Requires 48 week application
      2. Minimally better than Placebo for cure rates
      3. Partial clearance rates are also poor

ciclopirox (C0055711)

ConceptsOrganic Chemical (T109) , Pharmacologic Substance (T121)
Englishciclopirox, CICLOPIROX PREPARATION, cyclopirox
Spanishciclopirox
CreditsDerived from the NIH UMLS (Unified Medical Language System)


Loprox (C0733447)

ConceptsOrganic Chemical (T109) , Pharmacologic Substance (T121)
EnglishLoprox
CreditsDerived from the NIH UMLS (Unified Medical Language System)


Penlac (C1130459)

ConceptsOrganic Chemical (T109) , Pharmacologic Substance (T121)
EnglishPenlac
CreditsDerived from the NIH UMLS (Unified Medical Language System)



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