Dermatology Book

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Benzoyl Peroxide

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  1. Indication
    1. Acne Vulgaris
  2. Mechanism
    1. Comedolytic
    2. Kills follicular bacteria
    3. Resistance cannot develop
  3. Preparations
    1. Pure
      1. Cream 5%, 10%
      2. Gel 2.5%, 5%, 10%
      3. Lotion 5%, 10%
    2. Combination
      1. Benzoyl peroxide with Erythromycin (Benzamycin)
        1. Gel 50 mg benzoyl peroxide and 30 mg Erythromycin
        2. Apply to skin bid, morning & evening
        3. May cause skin dryness, erythema, Pruritus
      2. Benzoyl peroxide/sulfur (Sulfoxyl Regular or Strong)
        1. Lotion
          1. Benzoyl 5%, Sulfur 2%
          2. Benzoyl 10%, Sulfur 5%
        2. Apply qd or bid
        3. May cause skin dryness and Contact Dermatitis
  4. Application
    1. Apply to clean skin each day for 3 days
    2. Slowly increase strength of application
    3. Later increase time left on skin
  5. Adverse Effects
    1. May cause skin dryness or irritation
      1. Use water based instead of acetone or Alcohol product
      2. Use Lotion or cream instead of gel
    2. Bleaches hair and skin

Benzoyl Peroxide (C0005088)

Definition (MSH)A peroxide derivative that has been used topically for BURNS and as a dermatologic agent in the treatment of ACNE and POISON IVY DERMATITIS. It is used also as a bleach in the food industry.
Definition (NCI)A peroxide with antibacterial, irritant, keratolytic, comedolytic, and anti-inflammatory activity. Upon topical application, benzoyl peroxide decomposes to release oxygen which is lethal to the bacteria Proprionibacterium acnes. Due to its irritant effect, benzoyl peroxide increases turnover rate of epithelial cells, thereby peeling the skin and promoting the resolution of comedones. Benzoyl peroxide is used in the treatment of acne vulgaris.
ConceptsOrganic Chemical (T109) , Pharmacologic Substance (T121)
MSHD001585
EnglishBenzoyl Peroxide, Benzoyl peroxide - chemical, Benzoyl peroxide -RETIRED-, BENZOYL PEROXIDE PREPARATION, Benzoyl peroxide product, Benzoyl Superoxide, Benzyl peroxide, Dibenzoyl Peroxide, Diphenylglyoxal Superoxide
Spanishperoxido de bencilo, peroxido de benzilo, peroxido de benzoilo-RETIRADO-, producto con peroxido de benzoilo
Parent ConceptsBenzoic Acids (C0600423), Anti-Infective Agents, Local (C0003205), [DE752] ANTIACNE AGENTS, TOPICAL (C0973530), Benzoyl Peroxide (C0005088), Skin anti-infective (C0304580), Benzoic acid or derivative (C0578497), Reason not stated concept (C1276325), Drug allergen (C1320237), Contact allergen (C1320247), Duplicate concept (C1274013)
SourcesMSH, MTHSPL, NCI, NDFRT, RXNORM, SCTSPA, SNOMEDCT, VANDF
Derived from the NIH UMLS (Unified Medical Language System)



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