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Pemphigoid GestationisAka: Herpes Gestationis

Pathophysiology
1. Autoimmune skin disorder
2. Associated with HLA-DR3, and HLA-DR4
Associated conditions
1. Grave's Disease
2. Choriocarcinoma or Molar Pregnancy (rare)
Signs
1. Vesicles and bullae form on abdomen, extremities
Management
1. Increased antepartum observation
2. Oral Antihistamines
3. Topical Corticosteroids
4. Systemic Corticosteroids in severe cases
Complications
1. Preterm delivery
2. Small for Gestational Age infant
Course
1. Onset in second-half of pregnancy
2. Improves in late pregnancy
3. May be exacerbated in early postpartum period
4. May recur in future pregnancies

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This page was written by Scott Moses, MD. This page was last revised before 5/10/08, prior to consistent tracking of revision date. This page was last published on 5/10/2008. Please send comments and questions to the editor. Contact information may be found on the page About the Family Practice Notebook. These pages are best viewed with Microsoft Internet Explorer 6.0.