http://www.fpnotebook.com/

Intrahepatic Cholestasis of Pregnancy

See Also
1. Pruritus in Pregnancy
Epidemiology
1. Incidence: 2-10% of pregnancies
Symptoms
1. Severe Pruritus in third trimester of pregnancy
2. Pruritus localized to trunk and extremities
Signs
1. No rash
2. No Jaundice in mild form (Prurigo gravidarum)
Labs
1. Serum bile acids >4 (>16 confers adverse fetal outcome)
Management
1. Oral Antihistamines
2. Ursodeoxycholic Acid (Ursodiol)
3. Increased antepartum observation
4. Plan delivery by 38 weeks gestation
Course
1. Resolves with delivery
Complications
1. Preterm delivery
2. Meconium-stained amniotic fluid
3. Intrauterine Fetal Demise

Navigation Tree

Please see the Terms and Conditions. Please also see the privacy statement regarding advertising on this page. Although access to this page is not restricted, the information found here is intended for use by medical providers. Patients should address specific medical concerns with their physicians.

This page was written by Scott Moses, MD. This page was last revised before 5/10/08, prior to consistent tracking of revision date. This page was last published on 3/22/2010. Please send comments and questions to the editor. Contact information may be found on the page About the Family Practice Notebook. These pages are best viewed with Microsoft Internet Explorer 6.0.