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Lymphocutaneous NocardiosisAka: Nocardia brasiliensis, Nocardia, Nocardiosis

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  1. Pathophysiology
    1. Filamentous gram-positive bacteria
    2. Causes Nodular Lymphangitis
      1. Nocardia brasiliensis most common etiology
  2. Exposure risks
    1. Soil or plant debris (e.g. gardening)
    2. Splinters
  3. Signs
    1. Primary lesion follows one to six week incubation
      1. Tender nodular lesion develops at inoculation site
    2. Secondary lesions
      1. Erythematous Papules, Nodules develop up lymph chain
      2. Lesions ulcerate and drain purulent fluid
      3. Sinus tracts may form
    3. Other findings
      1. Fever
      2. Tender regional adenopathy occur
  4. Differential Diagnosis
    1. See Nodular Lymphangitis
  5. Labs
    1. Microscopic examination
      1. Gram Negative Bacteria
      2. Partially acid-fast organism
    2. Culture (slow growth may require several weeks)
      1. Routine fluid culture
      2. Culture of biopsied tissue
  6. Management
    1. TMP-SMZ DS (Septra DS or Bactrim DS): preferred
      1. Dose: 2 DS tablets PO tid for three months
      2. Complete Blood Count weekly (lower dose if cytopenia)
    2. Alternative antibiotics (based on sensitivity)
      1. Minocycline 100 mg PO bid for three months
      2. Amikacin
      3. Carbapenem antibiotics
      4. Quinolone antibiotics
  7. References
    1. Burgert (1999) Infect Dis Clin Pract 8:27
    2. Tobin (2001) Am Fam Physician 63:326

Nocardia (C0028240)

Definition (MSH)A genus of gram-positive, aerobic bacteria whose species are widely distributed and are abundant in soil. Some strains are pathogenic opportunists for man and animals.
ConceptsBacterium (T007)
MSHD009615
EnglishGenus Nocardia, Nocardia, Nocardia Trevisan 1889
Parent ConceptsActinobacteria class (C0600148), Nocardiaceae (C0028243), Partially acid-fast bacillus (C0445902), Aerobic Actinomycetes (C1265366)
SourcesAOD, CSP, LCH, MSH, NCBI, SCTSPA, SNOMEDCT
Derived from the NIH UMLS (Unified Medical Language System)


Nocardia Infections (C0028242)

Definition (MSH)Infections with bacteria of the genus NOCARDIA.
Definition (CSP)gram positive bacterial infection with bacteria of the genus Nocardia.
ConceptsDisease or Syndrome (T047)
ICD9039.9
MSHD009617
EnglishINFECT NOCARDIA, NOCARDIA INFECT, Nocardia Infection, Nocardia Infections, Nocardiosis
Spanishnocardiosis
Parent ConceptsActinomycetales Infections (C0001255), Nocardia Infections (C0028242), Disease due to Gram-positive bacteria (C1299528)
SourcesCSP, DXP, MSH, MTHICD9, NDFRT, SCTSPA, SNOMEDCT
Derived from the NIH UMLS (Unified Medical Language System)



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