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PemphigusAka: Intraepidermal Blister

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  1. See Also
    1. Bullous Disease
    2. Pemphigoid
  2. Definition
    1. Intraepidermal Acantholytic Blister
    2. Mnemonic: Pemphigus ends in S for Superficial
      1. Contrast with the deeper Pemphigoid
  3. Types: Primary forms of Pemphigus
    1. Deep Pemphigus (above Basal Cell Layer of Epidermis)
      1. Pemphigus Vulgaris (most common and most severe)
      2. Pemphigus Vegetans (rare Pemphigus Vulgaris variant)
      3. Drug-Triggered Pemphigus (umasks Pemphigus Vulgaris)
    2. Superficial Pemphigus (involves Stratum Granulosum)
      1. Pemphigus Foliaceus
      2. Pemphigus erythematosus (Senear-Usher Syndrome)
      3. Pemphigus herpetiformis
      4. Fogo selvagem
      5. Pemphigus
  4. Types: Secondary forms of Pemphigus
    1. Paraneoplastic Pemphigus
    2. Drug-Induced Pemphigus (similar to Pemphigus Foliaceus)
  5. Signs
    1. Flaccid Blister (superficial)
    2. Nikolsky's Sign
      1. Positive in Pemphigus Vulgaris
      2. Negative in Pemphigus Foliaceus (most superficial)
  6. Histology
    1. All pemphigus conditions show epidermal Acantholysis

Pemphigus (C0030807)

Definition (MSH)Group of chronic blistering diseases characterized histologically by ACANTHOLYSIS and blister formation within the EPIDERMIS.
Definition (CSP)group of chronic blistering diseases characterized histologically by acantholysis and blister formation within the epidermis.
ConceptsDisease or Syndrome (T047)
ICD9694.4, 694.4
MSHD010392
EnglishPemphigus
Spanishpenfigo
Parent ConceptsAutoimmune Diseases (C0004364), skin disorder (C0037274), Skin Diseases, Bullous (C0085932), Skin Diseases, Vesiculobullous (C0037275), Non-Neoplastic Skin Disorder (C1335042), Exanthema (C0015230), Pemphigus (C0030807), Autoimmune skin disease (C0406632), Duplicate concept (C1274013)
SourcesCOSTAR, CSP, ICD9CM, LCH, MSH, MTH, MTHICD9, NCI, NDFRT, SCTSPA, SNOMEDCT
Derived from the NIH UMLS (Unified Medical Language System)



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