http://www.fpnotebook.com/

Epidermolysis Bullosa Acquisita

See Also
1. Bullous Disease
2. Pemphigoid
Epidemiology
1. Mean age of onset: 50 years
Pathophysiology
1. Autoimmune Subepidermal Blistering condition
Signs
1. Trauma prone areas more commonly affected
2. Tense Blisters and Erosions over extensor surfaces
  1. Knuckles
  2. Dorsal hands
  3. Elbows
  4. Knees
  5. Ankles
3. Mucosal involvement common
  1. Oral, nasal, and esophageal mucosa
  2. Conjunctival mucosa
Labs
1. Histology
  1. Subepidermal Blister with inflammatory infiltrate
2. Immunofluorescence
  1. IgG deposits at dermal-epidermal junction
Complications
1. Scarring skin lesions (with associated milia)
Differential Diagnosis
1. Porphyria cutanea tarda
2. Hereditary epidermolysis bullosa (non-immune mediated)
3. Bullous Pemphigoid (non-scarring)
Course
1. Chronic waxing and waning course
References
1. Cotell (2000) Am J Emerg Med 18(3):288

Navigation Tree

Please see the Terms and Conditions. Please also see the privacy statement regarding advertising on this page. Although access to this page is not restricted, the information found here is intended for use by medical providers. Patients should address specific medical concerns with their physicians.

This page was written by Scott Moses, MD. This page was last revised before 5/10/08, prior to consistent tracking of revision date. This page was last published on 2/26/2010. Please send comments and questions to the editor. Contact information may be found on the page About the Family Practice Notebook. These pages are best viewed with Microsoft Internet Explorer 6.0.