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Peripheral Acting Adrenergic AntagonistAka: Reserpine, Serpasil, Guanethidine, Ismelin, Guanadrel, Hylorel
- Preparations
- Reserpine (Serpasil)
- Guanethidine (Ismelin)
- Guanadrel (Hylorel)
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| Definition (MSH) | An antihypertensive agent that acts by inhibiting selectively transmission in post-ganglionic adrenergic nerves. It is believed to act mainly by preventing the release of norepinephrine at nerve endings and causes depletion of norepinephrine in peripheral sympathetic nerve terminals as well as in tissues. |
| Concepts | Organic Chemical (T109)
, Pharmacologic Substance (T121)
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| English | Guanethidine, GUANETHIDINE PREPARATION, Octadine, Oktadin |
| Spanish | guanetidina |
| Credits | Derived from the NIH UMLS (Unified Medical Language System)
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| Definition (MSH) | An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. Reserpine inhibits the uptake of norepinephrine into storage vesicles resulting in depletion of catecholamines and serotonin from central and peripheral axon terminals. It has been used as an antihypertensive and an antipsychotic as well as a research tool, but its adverse effects limit its clinical use. |
| Definition (CSP) | alkaloid isolated from the root of Rauwolfia species, used as an antihypertensive and sedative. |
| Definition (NCI) | An alkaloid, derived from the roots of Rauwolfia serpentine and vomitoria, and an adrenergic uptake inhibitor with antihypertensive effects. Reserpine is lipid soluble and can penetrate blood-brain barrier. This agent binds and inhibits catecholamine pump on the storage vesicles in central and peripheral adrenergic neurons, thereby inhibiting the uptake of norepinephrine, dopamine serotonin into presynaptic storage vesicles. This results in catecholamines and serotonin lingering in the cytoplasm where they are destroyed by intraneuronal monoamine oxidase, thereby causing the depletion of catecholamine and serotonin stores in central and peripheral nerve terminals. Depletion results in a lack of active transmitter discharge from nerve endings upon nerve depolarization, and consequently leads to a decreased heart rate and decreased arterial blood pressure as well as sedative effects. |
| Concepts | Organic Chemical (T109)
, Pharmacologic Substance (T121)
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| English | Reserpine, RESERPINE PREPARATION |
| Spanish | reserpina |
| Credits | Derived from the NIH UMLS (Unified Medical Language System)
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| Concepts | Organic Chemical (T109)
, Pharmacologic Substance (T121)
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| English | guanadrel, GUANADREL PREPARATION |
| Spanish | guanadrel |
| Credits | Derived from the NIH UMLS (Unified Medical Language System)
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| Concepts | Organic Chemical (T109)
, Pharmacologic Substance (T121)
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| English | Celltech brand of guanadrel sulfate, Hylorel |
| Credits | Derived from the NIH UMLS (Unified Medical Language System)
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