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Esmolol HydrochlorideAka: Brevibloc
- Mechanism
- Selective Beta Blocker
- Indications
- Atrial Fibrillation Rate Control
- Emergent Hypertension Management
- Pharmacokinetics
- Half-life: 9 minutes
- Duration of action: 15-20 minutes
- Dosing: Intravenous
- Preparation: 2.5g (10 ml ampule) in 250 ml (10 mg/ml)
- Load: 250-500 ug/kg over 1 min (70 kg: 35 mg, 3.5 ml)
- Infusion:
- Start 25-50 ug/kg/min IV (70 kg: 10 ml/h)
- Titrate up 25-50 ug/kg q5 min to max 300 ug/kg/min
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| Concepts | Organic Chemical (T109)
, Pharmacologic Substance (T121)
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| English | Baxter brand of esmolol hydrochloride, Boots brand of esmolol hydrochloride, Brevibloc, Prasfarma brand of esmolol hydrochloride |
| Credits | Derived from the NIH UMLS (Unified Medical Language System)
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Esmolol hydrochloride (C0700606)
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| Definition (NCI) | The hydrochloride salt form of esmolol, a short and rapid-acting beta adrenergic antagonist belonging to the class II anti-arrhythmic drugs and devoid of intrinsic sympathomimetic activity. Esmolol hydrochloride competitively blocks beta1-adrenergic receptors in cardiac muscle and reduces the contractility and cardiac rate of heart muscle, thereby decreasing cardiac output and myocardial oxygen demands. This agent also decreases sympathetic output centrally and blocks renin secretion. At higher doses, esmolol hydrochloride also blocks beta-2 receptors located in bronchial and vascular smooth muscle, thereby leading to smooth muscle relaxation. |
| Concepts | Organic Chemical (T109)
, Pharmacologic Substance (T121)
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| English | Esmolol hydrochloride, ESMOLOL HYDROCHLORIDE PREPARATION, Esmolol hydrochloride product |
| Spanish | clorhidrato de esmolol, producto con clorhidrato de esmolol |
| Credits | Derived from the NIH UMLS (Unified Medical Language System)
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