Cardiovascular Medicine Book

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Central Adrenergic Agonist

Aka: Central Adrenergic Agonist, Clonidine, Catapres, Methyl-Dopa, Aldomet, Guanabenz, Wytensin
  1. See Also
    1. Alpha Adrenergic Antagonist (e.g. Prazosin)
    2. Clonidine Overdose
  2. Indications (Clonidine)
    1. Hypertension
    2. Vasomotor Symptoms of Menopause
    3. Tic Management
  3. Mechanism
    1. See Alpha Adrenergic Receptor
  4. Precautions
    1. Acute withdrawal risk (do not stop suddenly)
      1. Especially if Clonidine dose >1.2 mg per day
  5. Preparations
    1. Clonidine (Catapres)
      1. Start: 0.2 mg PO load
      2. Titrate 0.1 mg/hour to:
        1. Maximum of 0.7 mg
        2. Diastolic Blood Pressure drops more than 20 mmHg
    2. Methyl-Dopa (Aldomet)
    3. Guanabenz (Wytensin)

Catapres (C0699881)

Concepts Organic Chemical (T109) , Pharmacologic Substance (T121)
MSH D003000
English Catapresan, Catapressan, catapresan, catapres, catapre, Catapres
Sources
Derived from the NIH UMLS (Unified Medical Language System)


Wytensin (C0018313)

Concepts Organic Chemical (T109) , Pharmacologic Substance (T121)
MSH D006143
English Wyeth-Ayerst of Guanabenz Acetate, Wyeth Ayerst of Guanabenz Acetate, Acetate Wyeth-Ayerst, Guanabenz, Guanabenz Acetate Wyeth-Ayerst, Wytensin
Sources
Derived from the NIH UMLS (Unified Medical Language System)


Guanabenz (C0018312)

Definition (MSH) An alpha-2 selective adrenergic agonist used as an antihypertensive agent.
Concepts Organic Chemical (T109) , Pharmacologic Substance (T121)
MSH D006143
SnomedCT 372867002, 82951001
English 2,6-Dichlorobenzylideneaminoguanidine, Guanabenz, 2,6 Dichlorobenzylideneaminoguanidine, Hydrazinecarboximidamide, 2-((2,6-dichlorophenyl)methylene)-, guanabenz, Guanabenz [Chemical/Ingredient], Guanabenz (product), Guanabenz (substance), GUANABENZ
Swedish Guanabenz
Czech guanabenz
Finnish Guanabentsi
Russian GUANABENZ, ГУАНАБЕНЗ
Japanese グアナベンツ, グアナベンズ
Polish Guanabenz
Spanish guanabenz (producto), guanabenz (sustancia), guanabenz, Guanabenzo
French Guanabenz
German Guanabenz
Italian Guanabenzo
Portuguese Guanabenzo
Sources
Derived from the NIH UMLS (Unified Medical Language System)


Clonidine (C0009014)

Definition (MSH) An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonly used in the management of HYPERTENSION.
Definition (CHV) a hypertension treatment drug
Definition (NCI) The active ingredient in a drug used to treat high blood pressure. It is also being studied in the treatment of certain types of cancer pain. It blocks the release of chemicals from nerve endings that make blood vessels constrict (get narrower). Clonidine is a type of antihypertensive agent and a type of alpha-adrenergic agonist.
Definition (NCI) An imidazoline derivate and centrally-acting alpha-adrenergic agonist, with antihypertensive activity. Clonidine binds to and stimulates central alpha-2 adrenergic receptors, thereby reducing the amount of norepinephrine (NE) release and thus decreasing sympathetic outflow to the heart, kidneys, and peripheral vasculature. The reduction in sympathetic outflow leads to decreased peripheral vascular resistance, decreased blood pressure, and decreased heart rate. In addition, clonidine binds to imidazoline receptor subtype 1 (I1), which may also contribute to a reduction in blood pressure.
Definition (CSP) alpha-2 adrenergic agonist that crosses the blood-brain barrier; acts centrally by reducing sympathetic tone, resulting in a fall in diastolic and systolic blood pressure and a reduction in heart rate; also acts peripherally.
Concepts Organic Chemical (T109) , Pharmacologic Substance (T121)
MSH D003000
SnomedCT 22139009, 372805007, 62782004
English Clofenil, Clonidine, Klofenil, 1H-Imidazol-2-amine, N-(2,6-dichlorophenyl)-4,5-dihydro-, N-(2,6-Dichlorophenyl)-4,5-dihydro-1H-imidazol-2-amine, clonidine, clonidine (medication), Clonidine [Chemical/Ingredient], CLONIDINE, cloNIDine, Clonidine (product), Clonidine (substance)
Swedish Klonidin
Czech klonidin
Finnish Klonidiini
Russian KHLOFAZOLIN, GEMITON, KATAPRESAN, KLOFELIN, KLONIDIN, ГЕМИТОН, КАТАПРЕСАН, КЛОНИДИН, КЛОФЕЛИН, ХЛОФАЗОЛИН
Japanese クロニジン塩酸塩, カタプレス, クロニジン, 塩酸クロニジン
Croatian KLONIDIN
Polish Klonidyna
Spanish clonidina (producto), clonidina (sustancia), clonidina, Clonidina
French Clonidine
German Clonidin
Italian Clonidina
Portuguese Clonidina
Sources
Derived from the NIH UMLS (Unified Medical Language System)


Aldomet (C0591055)

Concepts Amino Acid, Peptide, or Protein (T116) , Pharmacologic Substance (T121)
MSH D008750
English aldomet, Aldomet, Biopat Brand of Methyldopa, Cahill May Roberts Brand of Methyldopa, Merck Brand of Methyldopa, Merck Sharp & Dohme Brand of Methyldopa, Methyldopa Biopat Brand, Methyldopa Merck Brand
Sources
Derived from the NIH UMLS (Unified Medical Language System)


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