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Central Adrenergic AgonistAka: Clonidine, Catapres, Methyl-Dopa, Aldomet, Guanabenz, Wytensin

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  1. See Also
    1. Alpha Adrenergic Antagonist (e.g. Prazosin)
  2. Indications (Clonidine)
    1. Hypertension
    2. Vasomotor Symptoms of Menopause
    3. Tic Management
  3. Mechanism
    1. See Alpha Adrenergic Receptor
  4. Precautions
    1. Acute withdrawal risk (do not stop suddenly)
      1. Especially if clonidine dose >1.2 mg per day
  5. Preparations
    1. Clonidine (Catapres)
      1. Start: 0.2 mg PO load
      2. Titrate 0.1 mg/hour to:
        1. Maximum of 0.7 mg
        2. Diastolic Blood Pressure drops more than 20 mmHg
    2. Methyl-Dopa (Aldomet)
    3. Guanabenz (Wytensin)

Clonidine (C0009014)

Definition (MSH)An alpha-2 adrenergic agonist that crosses the blood-brain barrier. Clonidine acts centrally by reducing sympathetic tone, resulting in a fall in diastolic and systolic blood pressure and a reduction in heart rate. It also acts peripherally, and this peripheral activity may be responsible for the transient increase in blood pressure seen during rapid intravenous administration. (From Martindale, the Extra Pharmacopoeia, 30th ed, p350)
Definition (CSP)alpha-2 adrenergic agonist that crosses the blood-brain barrier; acts centrally by reducing sympathetic tone, resulting in a fall in diastolic and systolic blood pressure and a reduction in heart rate; also acts peripherally.
ConceptsOrganic Chemical (T109) , Pharmacologic Substance (T121)
MSHD003000
EnglishClofenil, Clonidine, CLONIDINE PREPARATION, Klofenil
Spanishclonidina
Parent ConceptsImidazoles (C0020924), Antihypertensive Agents (C0003364), Imidazolines (C1449836), ANTIHYPERTENSIVES,OTHER (C0350167), Central alpha-adrenoceptor agonist (C0360167), Alpha 2 adrenergic agonist (C1268904), Drugs used to treat addiction (C1629845), Adrenergic alpha-Agonists (C0001640)
SourcesAOD, CSP, LCH, LNC, MSH, MTHSPL, NCI, NDFRT, PDQ, RXNORM, SCTSPA, SNOMEDCT, USPMG, VANDF
Derived from the NIH UMLS (Unified Medical Language System)


Guanabenz (C0018312)

Definition (MSH)An alpha-2 selective adrenergic agonist used as an antihypertensive agent.
ConceptsOrganic Chemical (T109) , Pharmacologic Substance (T121)
MSHD006143
EnglishGuanabenz, GUANABENZ PREPARATION
Spanishguanabenz
Parent ConceptsGuanidines (C0018320), ANTIHYPERTENSIVES,OTHER (C0350167), Central alpha-adrenoceptor agonist (C0360167), Alpha 2 adrenergic agonist (C1268904), Adrenergic alpha-Agonists (C0001640)
SourcesMSH, NDFRT, RXNORM, SCTSPA, SNOMEDCT, USPMG, VANDF
Derived from the NIH UMLS (Unified Medical Language System)


Wytensin (C0018313)

ConceptsOrganic Chemical (T109) , Pharmacologic Substance (T121)
MSHD006143
EnglishWytensin
SourcesMSH, RXNORM
Derived from the NIH UMLS (Unified Medical Language System)


Aldomet (C0591055)

ConceptsAmino Acid, Peptide, or Protein (T116) , Pharmacologic Substance (T121)
MSHD008750
EnglishAldomet, Biopat Brand of Methyldopa, Cahill May Roberts Brand of Methyldopa, Merck Brand of Methyldopa, Merck Sharp & Dohme Brand of Methyldopa, Methyldopa Biopat Brand, Methyldopa Merck Brand
SourcesMSH, NCI, RXNORM
Derived from the NIH UMLS (Unified Medical Language System)


Catapres (C0699881)

ConceptsOrganic Chemical (T109) , Pharmacologic Substance (T121)
MSHD003000
EnglishCatapres, Catapresan, Catapressan
SourcesMSH, MTH, NCI, PDQ, RXNORM
Derived from the NIH UMLS (Unified Medical Language System)



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